A Histochemical Study of Fibrinolytic Activity and Content of Protease in Mast Cells

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Abstract
In connective tissues of the rat, rich in mast cells, and in isolated rat mast cells, the fibrinolytic activity was studied by a histochemical method, based on lytic action of tissue sections or isolated cells on a thin fibrin layer. A high plasminogen activator activity was found in the small blood vessels in the tissues. In contrast, low fibrinolytic activity as well as low proteolytic activity was observed in isolated mast cells. Mast cell granules, released by means of Compound 48/80 in vitro and in vivo, contained low protease activity and little or no plasminogen activator. The previously reported high fibrinolytic activity of tissues rich in mast cells is therefore better explained by the fact that mast cells and small blood vessels, rich in plasminogen activator, occur simultaneously in these tissues.

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