DIFFERENT BIOLOGICAL TARGETS FOR RESINIFERATOXIN AND PHORBOL 12-MYRISTATE 13-ACETATE
- 1 January 1980
- journal article
- research article
- Vol. 40 (5) , 1400-1404
Abstract
The phorbol-related diterpene ester resiniferatoxin is at least 100-fold more inflammatory for the mouse ear than is the potent tumor promoter phorbol 12-myristate 13-acetate, but is nonpromoting. Resiniferatoxin is 100- to 1000-fold less active than is phorbol 12-myristate 13-acetate in in vitro assays with chicken and mouse fibroblasts. Resiniferatoxin and phorbol 12-myristate 13-acetate may have different primary target sites (receptors) and the fibroblast target may be homologous to that involved in promotion.This publication has 10 references indexed in Scilit:
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