The metabolism of carbohydrates in normal and in pathologic skin has been studied by a number of investigators without revealing its general pattern. A few isolated facts related to this problem have been ascertained, but relatively few of definite and unquestioned significance. There is disagreement about even some of the fundamentals. The solution of the problem has been difficult in many respects because of the lack of reliable quantitative methods of analysis for small portions of skin. Relatively recent developments have improved this situation. Consequently it seems propitious to again make a careful analysis and survey of the dextrose and glycogen content of normal skin, so that comparisons with pathologic skin may be more significant. A rather wide range of values has been quoted for the normal dextrose content of human skin. Only those of rather recent publication are considered here, since the older methods of determining such values are