Cefoperazone for the Treatment of Acute Urinary Tract Infection: Multicentered Comparative and Noncomparative Studies

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Abstract
Two separate multicentered studies evaluated the efficacy and safety of cefoperazone for the therapy of patients with acute bacterial urinary tract infections. A noncomparative study involved 198 patients, 114 of whom were evaluated for efficacy of the drug. Satisfactory clinical responses occurred in 89% of the patients. The primary pathogen was eliminated during therapy in 91 % of infections, including 60 of 61 involving Escherichia coli, 13 of 19 involving Pseudomonas aeruginosa, 5 of 5 involving Streptococcus jaecalis, and 32 of 39 involving other bacteria. Adverse reactions possibly related to therapy with cefoperazone included diarrhea in 5% of patients, rash in 1 %, and pain at the site of injection in 2%. In a multicentered comparative study in which patients were randomly assigned to treatment groups, 58 evaluable patients were treated with cefoperazone and 49 were treated with a comparative agent (25 with cefamandole and 24 with an aminoglycoside). Satisfactory clinical responses occurred in 100% of those given cefoperazone and in 97% of those given a comparative agent. The primary pathogen was eradicated during therapy in 87% of those treated with cefoperazone and in 95% of those treated with a comparative agent (88% of those given an aminoglycoside). Seventy-nine percent of bacteriologic failures occurred in complicated infections. Adverse reactions occurred in 5.7% and 6.3% of patients treated with cefoperazone and a comparative agent, respectively. Cefoperazone administered every 12 hr is safe and appears to be as effective for the therapy of urinary tract infection as previously established antibiotics.

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