EXPERIMENTAL EXAMINATION OF THE MECHANISM OF PYRAMIDON EFFECT: III. EFFECT OF HIGH PYRAMIDON DOSES ON THE GLUTAMIC ACID–OXALOACETIC ACID TRANSAMINASE ACTIVITY IN SERUM
- 1 August 1960
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 38 (8) , 899-901
- https://doi.org/10.1139/o60-111
Abstract
In five rabbits, the changes of glutamic acid – oxaloacetic acid transaminase (SGOT) activity in serum were examined after a Pyramidon treatment in which 75% of the single lethal dose was given for 5 days, divided in three doses. Depending on the individual sensitivity, SGOT activity became from 3 to 8 times higher. This increase appeared to be a result of extensive renal lesions.Keywords
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