Actinic Keratosis: The Key Event in the Evolution from Photoaged Skin to Squamous Cell Carcinoma
- 23 February 2004
- journal article
- review article
- Published by S. Karger AG in Skin Pharmacology and Physiology
- Vol. 17 (2) , 67-76
- https://doi.org/10.1159/000076016
Abstract
Skin aging is the result of intrinsic and extrinsic factors. Extrinsic aging, also called photoaging, is mainly caused by ultraviolet radiation from the sun and leads to a state which has been termed dermatoheliosis. The aim of this article is to provide an overview of photoaged skin addressing actinic keratoses (AKs) in particular. This review will describe the clinical features of photoaged skin and briefly summarize the underlying histological, photobiochemical and molecular mechanisms responsible for photoaging. The concept of the disease continuum from AK to squamous cell carcinoma will also be presented. A special focus will be on established and new therapeutic approaches to undo photoinduced skin damage.Keywords
This publication has 74 references indexed in Scilit:
- Cigarette smoking–associated elastotic changes in the skinJournal of the American Academy of Dermatology, 1999
- Diclofenac/Hyaluronic AcidDrugs & Aging, 1999
- Mitochondrial DNA Deletions in Human Skin Reflect Photo- Rather Than Chronologic AgingJournal of Investigative Dermatology, 1998
- Effects of α-hydroxy acids on photoaged skin: Apilot clinical, histologic, and ultrastructural studyJournal of the American Academy of Dermatology, 1996
- Nonmelanoma skin cancer in the United States: IncidenceJournal of the American Academy of Dermatology, 1994
- Reduction of Solar Keratoses by Regular Sunscreen UseNew England Journal of Medicine, 1993
- Topical photodynamic therapy with endogenous porphyrins after application of 5-aminolevulinic acid: An alternative treatment modality for solar keratoses, superficial squamous cell carcinomas, and basal cell carcinomas?Journal of the American Academy of Dermatology, 1993
- Topical tretinoin in the treatment of aging skinJournal of the American Academy of Dermatology, 1988
- Topical tretinoin for photoaged skinJournal of the American Academy of Dermatology, 1986
- Dermabrasion of the scalp as a treatment for actinic damageJournal of the American Academy of Dermatology, 1986