Demethylation of C14 2,3,4-Trimethoxyphenylethylamine in Schizophrenics Before and After L-methionine Loading

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Abstract
Demethylation was compared in acute and chronic schizophrenics and in non-schizophrenics by the administration of C14 labeled 2,3,4-trimethoxyphenylethylamine (TMPEA). There was no significant difference in the urinary levels of the monodemethylated catabolites of TMPEA among any groups of patients. There was a significant decrease in demethylation in untreated chronic schizophrenics after 10 days of L-methionine orally; the non-schizophrenic group similarly given methionine did not change. This suggests the possibility of a biological weakness in schizophrenia.