Two regimens of sultamicillin in treating uncomplicated gonorrhoea.

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Abstract
Sultamicillin is a covalent union of ampicillin and the .beta. lactamase inhibitor, sulbactam (CP-45,899). Two studies were conducted to assess its efficacy in treating uncomplicated gonorrhea. In the 1st study treatment comprised sultamicillin 1.5 g and probenecid 1 g; 124 (89.2%) of 139 patients responded including 7 of 11 patients harboring .beta.-lactamase (penicillinase) producing strains of Neisseria gonorrhoeae (PPNG). In the 2nd study sultamicillin 2.25 g and probenecid 1 g were given; 122 (93.8%) of 130 patients responded. Only 2 of 7 pharyngeal infections resolved, and if pharyngeal infections are excluded the overall cure rate rose to 95.3%. Thirteen of 14 patients infected with PPNG strains were cured by the larger dose. Side effects were mild and transitory. Thus, sultamicillin 2.25 g plus probenecid 1 g is an effective regimen to treat uncomplicated rectal and genital gonorrhoea and is useful for treating infections with PPNG strains. Most .beta.-lactamase resistant antimicrobials must be given parenterally; sultamicillin is given by mouth.