Induction of Epidermal Growth Factor by Tri-Iodo-L-Thyronine in the Submandibular Glands of Mice with Testicular Feminization

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Abstract
The content of epidermal growth factor (EGF) as a high molecular weight complex (HMW-EGF) in the submandibular glands of mice was measured simply by a single radial immunodiffusion method. In female mice, the amount of HMW-EGF was increased 10-fold by tri-iodo-L-thyronine (T3) and 60-fold by 5α-dihydro-testosterone (5α-DHT). In mice with testicular feminization (Tfm), which are genetically deficient in androgen receptor, T3 but not 5α-DHT increased the HMW-EGF from a non-detectable level to 5.4±0.94 μg/mg protein. It was concluded that EGF is also synthesized under the control of thyroid hormone in vivo, and that androgen was not involved in this induction of EGF by thyroid hormone.

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