NE and ACh responses of intrapulmonary vessels from dog, swine, sheep, and man

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Abstract
The effects of norepinephrine (NE) and acetylcholine (ACh) on isometric force generation were studied in isolated helical strips of intrapulmonary arteries (IPA) and veins (IPV) (3-5 mm diam) from lungs of dog, sheep, swine, and man. Cummalative dose-effect relationships (10-minus8-10-minus 4 M) were determined. All strips contracted in a dose-related fashion when exposed to NE but responses of sheep and swineIPV were weak. Acetylcholine relaxed canine IPA and contracted human IPA, CANINEIPV, and sheep IPV in a dose-related manner. Sheep IPA and swine IPA and IPV were unresponsive to ACh. Human IPV were relaxed by ACh but this effect wasreversed at the highest concentration (10 minus 4 M) tested. All vascular stripscontracted well in a potassium-rich (127 mM) bathing medium. It is concluded thatintrapulmonary lobar vessels from man, dog, swine, and sheep are responsive to autonomicneurohormones but that quantitative as well as qualitative differences exist.

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