Production of the cysteine proteinase inhibitor cystatin C by rat Sertoli cells
- 30 March 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 300 (2) , 131-135
- https://doi.org/10.1016/0014-5793(92)80180-o
Abstract
The Sertoli cells of the rat testis produce cystatin C, a cysteine proteinase inhibitor. Primary culture of Sertoli cells secreted both unglycosylated and glycosylated forms of rat cystatin C. Despite the low concentration of cystatin C in rete testis fluid, equilibrium dissociation constants (K 1) for the interaction between cystatin C and lysosomal cathepsins indicate that this molecule could be involved in the local regulation of testicular cysteine proteinase activity which may be necessary for spermatogenesis and spermiogenesis.Keywords
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