Terpenoid biotransformation in mammals. V. Metabolism of (+)-citronellal, (±)-7-hydroxycitronellal, citral, (−)-perillaldehyde, (−)-myrtenal, cuminaldehyde, thujone, and (±)-carvone in rabbits

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Abstract
The metabolism of (+)-citronellal, (.+-.)-7-hydroxycitronellal, citral, (-)-perillaldehyde, (-)-myrtenal, cuminaldehyde, thujone, and (.+-.)-carvone was studied in rabbits. In (.+-.)-7-hydroxycitronellal, (-)-perillaldehyde, (-)-myrtenal and cuminaldehydes, both primary alcohols and carboxylic acids were formed. In (-)-citronellal and citral, regioselective oxidation was found and a trans-positioned methyl group was carboxylated in each case. In o-cuminaldehyde, reduction but not oxidation, was found.