Ocular Manifestations of Congenital Rubella Syndrome

Publisher Website
Google Scholar
Abstract
The congenital rubella syndrome is a welldescribed clinical entity. Gregg of Australia in 1941 first described congenital malformations following maternal rubella cases.1These defects included small, malnourished infants with unilateral or bilateral cataracts, sluggish pupillary response to light, nystagmus in the older babies, corneal haze that cleared, microphthalmus, heart lesions (usually patent ductus arteriosus), and an intolerance to atropine. This work was reviewed for the American ophthalmic literature by Reese in 1944.2 Charles Swan of Australia confirmed these observations in 1943 and also extended the spectrum to include deaf-mutism, cardiac defects without apparent ophthalmic defects, and microcephaly.3Evans in 1944 first described tooth abnormalities consisting of retarded eruption and hypoplasia of the tooth enamel.4Bruce Hamilton and associates5in 1948 and Morlet6in 1949 reported associated pigmentation of the retina in eyes without cataracts. Lundstrom in 1962 confirmed the above observations and found significant