Rapid Regression of Atherosclerosis Induced by Liver-Directed Gene Transfer of ApoE in ApoE-Deficient Mice
- 1 September 1999
- journal article
- other
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 19 (9) , 2162-2170
- https://doi.org/10.1161/01.atv.19.9.2162
Abstract
—Apolipoprotein E (apoE) is a multifunctional protein synthesized by the liver and tissue macrophages. ApoE-deficient mice have severe hyperlipidemia and develop accelerated atherosclerosis...Keywords
This publication has 48 references indexed in Scilit:
- Apolipoprotein E secretion by macrophages: its potential physiological functionsCurrent Opinion in Lipidology, 1996
- Plasma protein entry and retention in the vascular wall: possible factors in atherogenesisCanadian Journal of Physiology and Pharmacology, 1996
- Interaction of Apolipoprotein E with Laminin Increases Neuronal Adhesion and Alters Neurite MorphologyExperimental Neurology, 1995
- Effects of the apolipoprotein E polymorphism on uptake and transfer of cell-derived cholesterol in plasma.Journal of Clinical Investigation, 1995
- Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice.Journal of Clinical Investigation, 1995
- Apolipoprotein E (ApoE), a novel heparin-binding protein inhibits the development of Kaposi's sarcoma-like lesions in BALB/c nu/nu mice.The Journal of Experimental Medicine, 1994
- Symposium on regression of atherosclerosisEuropean Journal of Clinical Investigation, 1993
- Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein EScience, 1992
- Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cellsPublished by Elsevier ,1992
- Physicochemical and histological changes in the arterial wall of nonhuman primates during progression and regression of atherosclerosis.Journal of Clinical Investigation, 1984