Allergic drug reactions: an in vitro model using a mixed function oxidase complex to demonstrate antibodies with specificity for a practolol metabolite
- 1 September 1977
- journal article
- research article
- Published by Wiley in Clinical and Experimental Allergy
- Vol. 7 (5) , 423-428
- https://doi.org/10.1111/j.1365-2222.1977.tb01473.x
Abstract
Reactive metabolite products of the drug practolol were generated in vitro using the rat liver mixed function oxidase complex. The metabolites were spontaneously coupled to a non-agglutinating rabbit antibody to human O red blood cells, forming a metabolite-antibody reagent. This reagent was then used to passively sensitize human O red cells which subsequently acted as indicator cells for detecting anti-metabolite antibodies.This publication has 4 references indexed in Scilit:
- Studies on the in vitro metabolism of dimethylnitrosamine by rat liverToxicology, 1976
- Untoward effects associated with practolol: demonstration of antibody binding to epithelial tissue.BMJ, 1975
- Untoward effects associated with practolol administration: oculomucocutaneous syndrome.BMJ, 1975
- A SEROLOGICAL PROCEDURE THEORETICALLY CAPABLE OF DETECTING INCOMPLETE OR NON-PRECIPITATING ANTIBODIES TO SOLUBLE PROTEIN ANTIGENS1953