Disuse Atrophy of Muscle
- 1 January 1970
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 22 (1) , 27-30
- https://doi.org/10.1001/archneur.1970.00480190031005
Abstract
DENERVATION of striated muscle leads to characteristic histological, histochemical, physiological, and pharmacological changes which have been ascribed to the loss of a trophic influence of nerve on muscle. The exact nature of this trophic effect has not been determined, although the release of acetylcholine at the motor end-plate seems necessary to maintain the relative insensitivity of normal muscle fibers to this substance away from the end-plate region.1,2The observations of Miledi3,4suggest that an influence other than acetylcholine is also important. Eccles5has postulated the existence of a trophic substance which passes from nerve to muscle and is independent of neural activity. Since denervation of muscle leads to a loss of muscle activity, and disuse of muscle without denervation can also lead to change,6,7it seems necessary to consider the role of disuse alone in the pathogenesis of the denervation change. It has been demonstratedKeywords
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