SOME ASPECTS OF PHARMACOLOGY OF BUTIBUFEN, A NON-STEROIDAL ANTI-INFLAMMATORY AGENT

  • 1 January 1977
    • journal article
    • research article
    • Vol. 227  (1) , 130-141
Abstract
The anti-inflammatory, analgesic and antipyretic properties of butibufen, a non-steroidal compound, were assessed by a battery of standard tests on rats. Its activity as an anti-inflammatory agent was equivalent to ibuprofen and phenylbutazone. Butibufen was within the potency range of ibuprofen as an antipyretic and analgesic agent and greater than that of acetylsalicylic acid. The compound possessed the advantage of a low order of toxicity. Its ulcerogenicity was much lower than that of phenylbutazone. Therefore, butibufen appeared to offer potential safety and efficacy in the treatment of rheumatic diseases.