SOME EFFECTS OF PHLORIZIN AND PHLORETIN ON RENAL AMINO ACID REABSORPTION IN THE DOG

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Abstract
The effects of phlorizin and phloretin on amino acid reabsorption were studied using clearance techniques in dogs. At endogenous plasma amino acid concentrations no effects were demonstrable. At elevated amino acid levels phlorizin depressed the reabsorption of L-aspartic acid and L-lysine. Phloretin depressed the reabsorption of L-aspartic acid but had a slight enhancing effect on that of L-lysine. No definite effects were observed on L-alanine or glycine reabsorption. These results are not predictable from the observations of other workers that in the in vitro rat kidney cortex phlorizin increases amino acid concentrating ability while phloretin depresses it. Our results are not, however, incompatible with the in vitro observations since it is theoretically possible for an agent to enhance the concentrating ability of kidney cortex, and either depress or increase tubular reabsorption, depending on whether the predominant site of action is on the luminal or basal side of the proximal tubular cells.

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