A New Blood Compatible and Permselective Hollow Fiber Membrane for Hemodialysis

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Abstract
The authors have prepared a blood compatible and highly permselective hemodialysis membrane composed of polyether segmented nylon. This block copolymer was synthesized by polycondensation of bis-3-aminopropyl-poly(tetramethylene oxide) (PTMO) and poly(imino-1,3-bismethyl-cyclohexyl-iminoisophtharoyl) (NyBI) prepolymer obtained by polycondensation of 1,3-bis(aminomethyl)cyclohexane (B) and isophthalic acid (I). The molecular weight (MW) calculated from the number of end-groups was 16,000-21,000.In vitroblood compatibility was evaluated in terms of platelet adhesion onto the surface. PTMO-NyBI surfaces showed excellent platelet adhesion preventing properties. The PTMO-NyBI hollow fiber membrane was obtained by a drywet spinning process. The membranes had higher permeability coefficients for macromolecules ranging from MW 10,000 to 20,000 than polysulfone hollow fiber membrane (PS membrane), and had acceptably low albumin permeability for use as a dialysis membrane. Theex vivoblood compatibilities of PTMO-NyBI membrane and PS membrane were investigated by extracorporeal circulation in a pig model. The PTMO-NyBI membrane gave excellent results when assessing hemodialysis leukopenia, oxidative burst, and free platelet count decrease.ASAIO Journal1996;42:1019-1026.

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