Normal Standards, Repeatability, and Precision of Phenolsulfonphthalein Clearance Measures for Renal Function in Dairy Cattle

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Abstract
Twenty-eight dairy bull calves and 24 dairy cows were used in trials to determine normal standards for phenolsulfonphthalein (PSP) fractional clearance, PSP volume of distribution, and PSP volume clearance as measures of renal function. The mean PSP fractional clearances per minute were 0.0250 and 0.0431, the PSP volumes of distribution were 31.3 and 19.0% of body weight, and the corresponding PSP volume clearances as ml per kg of body weight were 7.48 and 8.00 in calves and cows, respectively. The repeatability and precision of the various PSP clearance measures were low, as determined from variability found in trials conducted in 20 bull calves and 22 cows on 2 successive days. The reason for this was not determined. It was suggested that both PSP fractional clearance and PSP volume clearance measures should be used as criteria of renal function.