Ocular Anti-inflammatory Action of a Lipoxygenase Inhibitor in the Rabbit
- 1 January 1985
- journal article
- Published by Mary Ann Liebert Inc in Journal of Ocular Pharmacology and Therapeutics
- Vol. 1 (4) , 383-390
- https://doi.org/10.1089/jop.1985.1.383
Abstract
Among all lipoxygenase inhibitors studied, REV 5901 was found to be the most potent one to reduce lens protein-induced ocular inflammation in rabbits. It reduced ocular inflammation effectively by either injection into the ear vein (10 mg/kg) (65% inhibition) or topical administration (50 microliters of 5% ointment) (40% inhibition). Local administration was less effective than intravenous injection presumably because of slower drug delivery into the eyes.Keywords
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