A New Synthesis for 1-Aminohydantoin and Nitrofurantoin
- 1 December 1959
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 11 (Supplement) , 108T-114T
- https://doi.org/10.1111/j.2042-7158.1959.tb10419.x
Abstract
A new synthesis for 1-aminohydantoin and nitrofurantoin is described. Derivatives of 1-aminohydantoin were prepared by condensation of semicarbazones with ethyl monochloroacetate in presence of sodium alkoxide in dry ethanol. The nature of this reaction is discussed and semicarbazones were shown to react as nucleophilic anions.Keywords
This publication has 2 references indexed in Scilit:
- Studies on Aminohydantoin Derivatives and Related Compounds. IYAKUGAKU ZASSHI, 1954
- Ueber die Hydrazino‐essigsäure. IIEuropean Journal of Inorganic Chemistry, 1898