IgG Subtype Is Correlated with Efficiency of Passive Protection and Effector Function of Anti-Herpes Simplex Virus Glycoprotein D Monoclonal Antibodies
- 1 October 1995
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 172 (4) , 1108-1111
- https://doi.org/10.1093/infdis/172.4.1108
Abstract
IgG subclasses differ in their effector functions in a variety of in vitro assays. To assess the effect of antibody subclass differences on in vivo protective efficacy against herpes simplex virus (HSV), a series of subclass switch mutants was made from an anti-HSV glycoprotein D monoclonal antibody. Purified antibody was examined for the ability to protect against HSV-2 challenge in mice. IgG2a was found to be more effective than IgG1. This correlated both with activity in antibody-dependent cell-mediated cytotoxicity and with efficiency of complement-mediated neutralization. These data suggest that optimization of passive immunization against HSV requires consideration of antibody subclass.Keywords
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