Using the False Discovery Rate Approach in the Genetic Dissection of Complex Traits: A Response to Weller et al.
Open Access
- 1 April 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 154 (4) , 1917-1918
- https://doi.org/10.1093/genetics/154.4.1917
Abstract
WELLER et al. ( 1998) proposed controlling the “false discovery rate” (FDR) or the expected proportion of false rejections within the class of rejected null hypotheses when performing preliminary genome scans, adopting the method of Benjamini and Hochberg ( 1995; hereafter BH). The BH procedure is as follows: for the ordered set of P values, P(1) ≤ … ≤ P(L) determine a largest j such that Pj ≤ jα/L, where α is the declared FDR. Then reject all hypotheses Hi that correspond to P(i), i = 1, …, j. The method controls the average proportion of false positives at 5% (say) across multiple studies, including those where no significances are found. However, this procedure does not provide information about the expected proportion of false positive results for a given experiment where some of the null hypotheses are rejected.Keywords
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