Interferon Production by Simian Lymphoblastoid Cell Lines2
- 1 July 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 53 (1) , 271-275
- https://doi.org/10.1093/jnci/53.1.271
Abstract
Six Iymphoblastoid cell cultures, established from tumors induced in cotton-topped and white-lipped marmosets with Herpesvirus saimiri (HVS) were studied for spontaneous interferon production over a period of 14 months. Five of 6 cell lines produced virus inhibitor at levels from 4 to 256 interferon U/ml. The cell lines were virus producing when first established in culture, but production of infectious HVS, formation of infectious centers in permissive cell cultures, and expression of virus-specific antigens by the cells decreased progressively during 14 months' cultivation, with little or no change in levels of interferon production.Keywords
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