THE COMPARATIVE EFFECTS OF SMALL INTRAVENOUS DOSES OF L-NOR-EPINEPHRINE UPON ARTERIAL PRESSURE AND PULSE RATE IN NOR-MOTENSIVE SUBJECTS AND IN HYPERTENSIVE PATIENTS BEFORE AND AFTER THORACOLUMBAR SYMPATHECTOMY

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Abstract
Single small doses of L-nor-epinephrine given intraven. to normotensive subjects, and to hypertensive patients before and after splanchnic-ectomy, produce single phase hypertensive responses with proportionate rises in systolic and diastolic arterial pressure as recorded by a Sanborn Electromanometer. No significant differences exist in the arterial pressure responses of normotensive subjects and pre-operative hypertensive patients. After thoracolumbar sympathectomy, some hypertensive patients show increased pressor responses to the smaller doses of intraven. L-nor-epinephrine. The pulse rates of hypertensive patients are significantly different from those of the normotensive subjects during pressor responses to L-nor-epinephrine. Normotensive subjects definitely slow their pulse rates, while hypertensive patients before operation fail to do so significantly. After splanchnicectomy, hypertensive patients do slow their pulse rates normally during hypertensive responses to intraven. L-nor-epinephrine.