CIS-DICHLORODIAMMINEPLATINUM(II) AND BLEOMYCIN IN TREATMENT OF ESOPHAGEAL CARCINOMA

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 62  (7) , 1041-1046
Abstract
Forty-seven patients withsquamous cell carcinoma of the esophagus were treated with a combination of cis-dichlorodiammine platinum (II) (cis-DDP) and bleomycin by infusion. cis-DDP at a dose of 3 mg/kg with mannitol and prehydration was given on day 1. On day 3, bleomycin was started as a 10-15-unit/m2 loading dose followed by a 10-15-unit/m2 24-h infusion for 4-7 days. Three groups of patients were treated: group 1 (no clinical evidence of metastatic disease) included 25 patients, all with no prior therapy; group 2 (measurable metastatic disease) included 13 patients, 8 previously treated with surgery and/or radiation; group 3 (known nonmeasurable metastatic disease) included 9 patients, all previously treated with surgery and/or radiation and/or chemotherapy. A 2nd course of therapy was given on day 28 to groups 2 and 3, and as soon after surgery as possible in group 1. Nineteen percent of patients had complete or partial response with another 44% having minor regressions. Toxic effects were renal effects, alopecia, nausea and vomiting and stomatitis. There were 2 drug-related deaths. The combination of cis-DDP and bleomycin is useful in the treatment of patients with squamous cell carcinoma of the esophagus.