Reversible gonadotropin Deficiency in Male Cushing's Dusease

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Abstract
Twelve adult males with documented active Cushing's disease were studied. Mean plasma testosterone (T) was significantly decreased: 1.8 ± 0.3 (SEM) ng/ml (N = 6.8 ± 0.5); gonadotropinmeasurements in 8 patients, in basal conditions and under LH-RH iv, showed a significant decrease in both FSH and LH. A further study of 11 patients in remission of Cushing's disease indicated a significant increase in plasma T and gonadotropins up to the normal range. One patient with an initia low T value had a normalized T while in remis sion, then a dramatic decrease when the diseasi relapsed. We conclude: a hypogonadotropic hypo gonadism is found in male Cushing's disease; i disappears as early as hypercortisolism is sup pressed. Some possible mechanisms are discussed.

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