Determination of the distribution of 131I in biosynthetically labelled [131]thyroxine isolated from the thyroid glands of rabbits and rats

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Abstract
The diazo-coupling technique for determining the distribution of 131I between the two rings of the thyroxine molecule has been applied to radioactive thyroxine purified from animal thyroids, and in one instance from a human thyroid. The results indicate that from the earliest time after administration of [131I]iodide when thyroxine samples could be obtained, the radioactive atoms were equally distributed between the rings of the thyronine nucleus.