Effects of Acetylcholine and Biogenic Amines on Pulmonary Smooth Muscle in the African Lungfish, Protopterus Aethiopicus

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Abstract
Smooth muscles from the glottis sphineter and pulmonary parenchyma were excised from freshly killed specimens of the African lungfish, Protopterus aethiopicus, and mounted in a bath of Ringer solution while responses to pharmacological agents were studied. Both muscle preparations gave qualitatively similar responses. Acetylcholine caused contraction which was abolished by pretreatment with atropine. Histamine and serotonin also contracted the muscles, their effects being diminshed by mepyramine and methysergide. Adrenaline and noradrenaline relaxed the muscle preparations. Neither regitine nor propranolol affected this response. Isoproterenol had a slight relaxing effect. Anoxia and hypercapnia did not influence the contractile state of the muscles.

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