Rapid, Simultaneous Quantification of Morphine, Codeine, and Hydromorphone by GC/MS
- 31 August 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 6 (5) , 235-237
- https://doi.org/10.1093/jat/6.5.235
Abstract
Morphine, codeine, and hydromorphone were extracted from blood or serum using a one step extraction. The extract was derivatized and the trifluoroacetyl opiates were quantified by GC/MS selected ion monitoring (SIM) using nalorphine as the internal standard. Calibration curves were linear and sensitivity as low as .02 mg/L for morphine and codeine, and .08 mg/L for hydromorphone, was achieved. Urine or tissue homogenates could be processed similarly after acid hydrolysis.This publication has 1 reference indexed in Scilit: