Ring-Opening Allylation of Semicyclic N,O-Acetals Catalyzed by a Lewis Acid
- 31 December 2001
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2001 (08) , 1225-1228
- https://doi.org/10.1055/s-2001-16067
Abstract
Ring-opening allylation of semicyclic N,O-acetals with allylic silanes is effectively catalyzed by a Lewis acid showing high diastereoselectivities. The synthetic utility of this method has been demonstrated in a stereoselective synthesis of an antimalarial agent, isofebrifugine.Keywords
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