Sorbistin, a new aminoglycoside antibiotic complex of bacterial origin. I. Production, isolation and properties.
- 1 January 1976
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 29 (11) , 1137-1146
- https://doi.org/10.7164/antibiotics.29.1137
Abstract
A strain of a new Pseudomonas sp. produced the aminoglycoside antibiotic complex, sorbistin, which was separated by ion-exchange chromatography into 3 bio-active components A1, A2 and B, and 2 bio-inactive components C and D. Sorbistins A1, A2 and B showed moderate intrinsic activity against a wide range of bacterial [and fungal] species and inhibited most of the aminoglycoside-resistant organisms. Sorbistin A1 exhibited the highest activity among the 3 bio-active components. Sorbistins showed low order of acute toxicity in mice.This publication has 2 references indexed in Scilit:
- Sorbistin, a new aminoglycoside antibiotic complex of bacterial origin. III. Structure determination.The Journal of Antibiotics, 1976
- Sorbistin, a new aminoglycoside antibiotic complex of bacterial origin. II. Isolation and taxonomy of sorbistin-producing organism.The Journal of Antibiotics, 1976