Synthesis of phosphodiester and triester derivatives of AZT with tethered N-methyl piperazine and N,N,N′ trimethylethylenediamine.
- 31 August 1993
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 3 (8) , 1547-1550
- https://doi.org/10.1016/s0960-894x(00)80015-3
Abstract
No abstract availableKeywords
This publication has 18 references indexed in Scilit:
- O-Alkyl-5',5'-dinucleoside phosphates as prodrugs of 3'-azidothymidine and cordycepinThe Journal of Organic Chemistry, 1992
- Improved brain delivery of AZT using a glycosyl phosphotriester prodrugJournal of Medicinal Chemistry, 1992
- Aryl phosphate derivatives of AZT retain activity against HIV1 in cell lines which are resistant to the action of AZTAntiviral Research, 1992
- The Synthesis and Biological Properties of some Aryl bis(Nucleosid-5′-yl) Phosphates Using Nucleosides with Proven Anti-HIV ActivityNucleosides and Nucleotides, 1992
- Lipophilic glycosyl phosphotriester derivatives of AZT: synthesis, NMR transmembrane transport study and antiviral activityJournal of Medicinal Chemistry, 1991
- Synthesis and biological evaluation of some cyclic phosphoramidate nucleoside derivativesJournal of Medicinal Chemistry, 1990
- Nuclease activity of 1,10-phenanthroline-copper: sequence-specific targeting.Proceedings of the National Academy of Sciences, 1986
- Zwitterionic 3'-O-acyl derivatives of thymidine 5'-phosphate as potential sources of intracellular thymidine 5'-phosphate in cells in cultureJournal of Medicinal Chemistry, 1986
- Nucleoside conjugates. 6. Synthesis and comparison of antitumor activity of 1-.beta.-D-arabinofuranosylcytosine conjugates of corticosteroids and selected lipophilic alcoholsJournal of Medicinal Chemistry, 1985
- Lipophilic 5'-alkyl phosphate esters of 1-.beta.-D-arabinofuranosylcytosine and its N4-acyl and 2,2'-anhydro-3'-O-acyl derivatives as potential prodrugsJournal of Medicinal Chemistry, 1982