Comparison of Fascin Expression in Anaplastic Large Cell Lymphoma and Hodgkin Disease
- 1 February 2003
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 119 (2) , 199-204
- https://doi.org/10.1309/eae3-tgpp-4a5r-va92
Abstract
Diagnostic difficulties sometimes arise in distinguishing anaplastic large cell lymphoma (ALCL) from Hodgkin disease (HD), especially the syncytial variant. Study of the biologic features of diagnostic Reed-Sternberg cells in HD, in search of specific markers for Reed-Sternberg cells, has suggested fascin as a relatively specific and sensitive marker. We studied the frequency of fascin expression in 30 ALCLs and 34 cases of classic HD, including 17 cases of the syncytial variant. Staining with CD30 and anaplastic lymphoma kinase (ALK)-1 also was performed in all cases. All ALCL and HD cases showed membranous and Golgi zone CD30 positivity. Fascin stained all HD cases but also stained 67% (20/30) of the ALCLs in a cytoplasmic pattern. Fascin positivity was observed in 59% (10/17) of T-cell ALCLs and 77% (10/13) of null-cell ALCLs; ALK-1–positive ALCLs, regardless of origin, were usually fascin-positive (91% [10/11]). In conclusion, fascin shows strong positivity in all cases of classic HD but also is positive in the majority of ALCLs, including ALK-1–positive and ALK-1–negative cases. Positive staining for fascin is not useful for distinguishing ALCL from HD. In some cases, fascin negativity may help rule out classic HD.Keywords
This publication has 9 references indexed in Scilit:
- Anaplastic large cell lymphoma: pathological, molecular and clinical featuresBritish Journal of Haematology, 2001
- A Hodgkin’s Disease Cell Line, KM-H2, Shows Biphenotypic Features of Dendritic Cells and B CellsInternational Journal of Hematology, 2001
- Expression of the Actin-Bundling Protein Fascin in Cultured Human Dendritic Cells Correlates with Dendritic Morphology and Cell DifferentiationJournal of Investigative Dermatology, 2000
- Detection of t(2;5) in Anaplastic Large Cell LymphomaThe American Journal of Surgical Pathology, 1999
- ALK Expression Defines a Distinct Group of T/Null Lymphomas (“ALK Lymphomas”) with a Wide Morphological SpectrumThe American Journal of Pathology, 1998
- Fascin and the Differential Diagnosis of Childhood Histiocytic LesionsPediatric and Developmental Pathology, 1998
- CD30‐positive large cell lymphomas (‘Ki‐1 lymphoma’) are associated with a chromosomal translocation involving 5q35British Journal of Haematology, 1990
- A translocation involving a specific breakpoint (q35) on chromosome 5 is characteristic of anaplastic large cell lymphoma (‘Ki‐1 lymphoma')British Journal of Haematology, 1989
- Preparation and purification of polymerized actin from sea urchin egg extracts.The Journal of cell biology, 1975