Eremophilane Sesquiterpenes from Cacalia ainsliaeflora
- 31 January 2002
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 68 (1) , 55-59
- https://doi.org/10.1055/s-2002-19872
Abstract
Chemical investigation of Cacalia ainsliaeflora afforded four new eremophilane sesquiterpenes (1 - 3, 5) and a known sesquiterpene (4), which were identified as 3β-angeloyloxy-8α-hydroxy-6β-methoxyeremophil-7(11),9(10)-dien-8,12-olide (1), 3β-angeloyloxy-6β,8α-dihydroxyeremophil-7(11),9(10)-dien-8,12-olide (2), 3β-angeloyloxy-8α-hydroxy-6β-ethoxyeremophil-7(11),9(10)-dien-8,12-olide (3), 3β-angeloyloxy-8-oxo-eremphila-6,9-dien-12-oic acid (4), and 3,8-oxo-eremophila-6,9-dien-12-oic acid (5) respectively. These compounds were assayed against Escherichia coli, Staphylococcus aureus and Bacillus subtilis, and compounds 1, 2, 4 and 5 showed weak antibacterial activity. The structures of the compounds were established by 1D and 2D NMR experiments.Keywords
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