On phenotyping with isoniazid: The use of urinary acetylation ratio and the uniqueness of antimodes. Study of two Amerindian populations
- 1 November 1987
- journal article
- research article
- Published by Springer Nature in Clinical Pharmacology & Therapeutics
- Vol. 42 (5) , 493-497
- https://doi.org/10.1038/clpt.1987.186
Abstract
Various conventions have been used to express the activity of polymorphic hepatic N-acetyltransferase of isoniazid. Among them, two of the most common are the "percentage of acetylisoniazid" and the "inactivation index." A third alternative convention is proposed, the "molar acetylation ratio," which showed the most clear-cut bimodal distribution when applied to the results obtained for Cuna and Teribe Amerindians living in Panama. Through this method a unique antimode was assigned to each Amerindian group and the same frequency of slow acetylators (24% to 29%) was found, unlike the results obtained by conventional approaches and antimodes derived from white populations.This publication has 1 reference indexed in Scilit:
- Distribution of hereditary blood antigens among Indians in Middle America. VIII. In PanamaAmerican Journal of Physical Anthropology, 1965