Abstract
With the licensure of the human papillomavirus (HPV) vaccine in the United States and many other countries, an understanding of the natural history of HPV infection is imperative for establishment of appropriate policies and guidelines for its use. Although our knowledge of the natural history of HPV infection in women has increased dramatically over the past decade, the natural history of HPV infection in men is less known. In this issue of the Journal, Partridge et al. present results from a longitudinal study of HPV infection in US men that is reminiscent of their earlier work on a similar cohort of female students from the same university [1]. In light of the imminent (and highly publicized) policy questions surrounding the appropriate vaccine target population, this study is timely in its contribution to the scarce, yet growing, literature on HPV infection in men.

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