EFFECT OF AFRICAN SWINE FEVER ON LYMPHOCYTE MITOGENESIS
- 1 January 1982
- journal article
- research article
- Vol. 46 (1) , 215-220
Abstract
The effect of African swine fever virus replication on pig T and B lymphocytes was studied by mitogen-driven assays. Liver attenuated isolates caused a marked suppressive effect which was dose- and time-dependent. This effect appeared to be mediated through a monokine. Live virulent isolates enhanced lymphocytes mitogenesis in most cases, with increased [3H]-thymidine uptake by T cells and increased Ig secretion by B cells. Killed preparation had no effect. These results are discussed in the light of the allergic response and immunopathological lesions produced by African swine fever virus infections.This publication has 27 references indexed in Scilit:
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