HUMAN PROTHROMBIN: QUANTITATIVE STUDIES ON THE PLASMA LABILE FACTOR AND THE RESTORATIVE EFFECTS OF NORMAL, HYPOFI-BRINOGENEMIC, AND HEMOPHILIC PLASMA ON THE PROTHROMBIN OF STORED PLASMA 1

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Abstract
The prothrombin time of human plasma rises during storage at refrigerator temp. due to deterioration of a labile factor. It can be restored by the admixture of plasma rendered prothrombin free by prior adsorption with BaSO4 Since plasma from a subject with congenital afibrinogenemia or plasma defibrinogenated by thrombin can similarly reactivate stored plasma, the labile factor is not fibrinogen. Hemophilic plasma also contains normal amts. of labile factor. The prothrombin time of plasma can be greatly influenced by alterations in the concn. of prothrombin, labile factor and fibrinogen. An elevated prothrombin time due at least, in part, to deficiency of labile factor is described in a patient with extensive involvement of the liver with malignant disease. Prothrombin-free barium sulfated plasma contains normal amts. of fibrinogen, labile factor and antihemophilic activity. Its use as a diluent in measuring prothrombin by the one stage technic is advantageous since in this way these non-prothrombin variables are adequately controlled. The prothrombic activity of human plasma determined by means of this dilution technic increases during storage at refrigerator temp. The explanation of this phenomenon is obscure.

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