Effects of Gonadotropin and Testosterone Treatments on Plasma Leptin Levels in Male Patients with Idiopathic Hypogonadotropic Hypogonadism and Klinefelter's Syndrome

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Abstract
Since little is known about the effects of gonadotropin and testosterone treatment on leptin levels in male hypogonadism, we determined fasting plasma leptin levels before and 3 months after treatment in 21 patients with idiopathic hypogonadotropic hypogonadism (IHH), 16 patients with Klinefelter's syndrome and 20 male controls. Patients with IHH were treated with hCG/human menopausal gonadotropin, whereas patients with Klinefelter's syndrome received T treatment. Plasma leptin levels were measured by an RIA with a sensitivity of 0.5 µg/L. Mean leptin levels in patients with IHH before treatment (9.23 ± 4.09 µg/L) were not significantly different from those in patients with Klinefelter's syndrome (7.29 ± 5.05 µg/L; z = - 1.41; P = 0.15). Leptin levels in both IHH and Klinefelter's syndrome groups were, however, significantly higher than in the normal men (3.91 ± 1.67 µg/L) (P < 0.001 and P < 0.01, respectively). Mean leptin levels did not change significantly 3 months after the initiation of gonadotropin (11.6 ± 6.44 µg/L) or T (8.32 ± 5.17 µg/L) treatment in either IHH or Klinefelter's syndrome. Our study demonstrated that mean plasma leptin levels are not influenced by short-term gonadotropin or T treatment in male hypogonadism.

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