Solid Phase Synthesis of Bicyclo[2.2.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Reductive Amination

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Abstract
Tandem Michael addition reactions of polymer bound acrylates with cyclohexenones and subsequent reductive amination was achieved, which after cleavage from the support under reductive, acidolytic or aminolytic conditions afforded a wide variety of bicyclo[2.2.2]octanes. The process may find application in combinatorial library synthesis.