In vitro BALB/3T3 cell transformation assay of nonoxynol‐9 and 1,4‐dioxane
- 1 January 1988
- journal article
- research article
- Published by Wiley in Environmental and Molecular Mutagenesis
- Vol. 11 (1) , 41-48
- https://doi.org/10.1002/em.2850110106
Abstract
The spermicidal surfactant nonoxynol‐9 (Igepal CO‐630, GAF Corp.) and a potential impurity, 1,4‐dioxane, were tested in the in vitro cell transformation assay using BALB/3T3 cells. Two treatment periods, 48 hr and 13 days, were used. Nonoxynol‐9, tested at levels up to 10 μg/ml, did not induce transformation, whereas dioxane was very active in the induction of type III foci in the cultured BALB/3T3 cells.Keywords
This publication has 11 references indexed in Scilit:
- The effect of cell passage on the susceptibility of BALB/3T3 clone A31-1-1 cells to 3-methylcholanthrene-induced morphological transformationEnvironmental Mutagenesis, 1987
- Effect of 3-aminobenzamide on the induction of toxicity and transformation by ethyl methanesulfonate and methylcholanthrene in BALB/3T3 cellsCarcinogenesis: Integrative Cancer Research, 1984
- Neoplastic transformation of balb 3T3 mouse embryo fibroblasts by the beef extract mutagen 2-amino-3-methylimidazo [4,5-d] quinolineCancer Letters, 1983
- Scanning electron microscopy of human spermatozoa after incubation with the spermicide nonoxynol-9Fertility and Sterility, 1983
- Transvaginal absorption and disposition of nonoxynol-9 in gravid ratsToxicology Letters, 1982
- Effect of nonoxynol-9, a detergent with spermicidal activity, on malignant transformation in vitroCarcinogenesis: Integrative Cancer Research, 1982
- Studies on nonoxynol-9. II. Intravaginal absorption, distribution, metabolism and excretion in rats and rabbitsContraception, 1980
- Studies of in vitro cell transformation and mutagenicity by surfactants and other compoundsFood and Cosmetics Toxicology, 1980
- In vitro transformation of hamster embryo cells with tryptophan pyrolysis products.Proceedings of the Japan Academy, Series B, 1977
- Toxicologic studies of alkylphenol polyoxyethylene surfactantsToxicology and Applied Pharmacology, 1969