Delayed cutaneous hypersensitivity and lymphocyte transformation: dissociation in atopic dermatitis

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Abstract
Studies of cell mediated immunity (CMI) in atopic dermatitis demonstrated various defects and frequently contradictory results. The true nature of immune dysfunction remains uncertain. Two aspects of CMI were examined: delayed cutaneous hypersensitivity and in vitro lymphocyte transformation. Responses were tested using the antigens Candida albicans and streptokinase-streptodornase (SKSD). Mean lymphocyte transformation was equal in atopic patients and controls, although a subgroup of severely dermatitic patients showed depressed responses. Cutaneous anergy was the rule in atopic patients (96% to candidin and 84% to SKSD). Although normal subjects showed good correlation between in vitro and cutaneous responses, atopic patients showed a significant lack of correlation. Many patients manifested cutaneous anergy in the face of normal lymphocyte transformation responses.

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