Studies on new aminoglycoside antibiotics, istamycins, from an actinomycete isolated from a marine envioment. II. Possible involvement of plasmid in istamycin production.
- 1 January 1980
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 33 (12) , 1510-1514
- https://doi.org/10.7164/antibiotics.33.1510
Abstract
Acriflavine treatment of an istamycin-producing Streptomyces tenjimariensis strain designated SS-939 resulted in a high frequency of isolates with reduced istamycin production. Some of these lost a particular plasmid present in the parent strain. Istamycin production by these isolates was largely restored by the addition of 2-deoxystreptamine (DOS) to the medium; the effect of DOS was small in the strain SS-939. Sodium palmitate stimulated production, especially when added together with DOS. These stimulative effects by DOS and palmitate were not exhibited in the presence of glucose (1.0%).This publication has 4 references indexed in Scilit:
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