Advances in cyclosporine pharmacology, measurement, and therapeutic monitoring.
Open Access
- 1 July 1989
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 35 (7) , 1299-1308
- https://doi.org/10.1093/clinchem/35.7.1299
Abstract
This review will focus on our current state of understanding of the cellular and molecular mechanisms by which CsA exerts immunosuppression and will present new information on: pharmacokinetic variability of CsA, selection of specimen and method for measuring CsA concentration, identity of CsA metabolites and their immunosuppressive and toxic activity, and the relationship between steady-state pre-dose concentrations of CsA in blood and response to treatment in transplant patients.Keywords
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