Inhibition of β-Lactamase in Neisseria gonorrhoeae by Sodium Clavulanate

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Abstract
Sodium clavulanate at subinhibitory concentrations affected the activity of penicillin G, ampicillin or amoxicillin on .beta.-lactamase-positive strains of N. gonorrhoeae as demonstrated by marked reduction in the minimal inhibitory concentrations of the drugs for the organisms. The compound did not affect the activity of these penicillins on .beta.-lactamase-negative strains of N. gonorrhoeae. It also had no effect on the activity of cefoxitin against .beta.-lactamase-negative or -positive strains. The reduction in minimal inhibitory concentrations of the penicillins for the .beta.-lactamase-positive organisms brought about by sodium clavulanate is probably due to inhibition of the .beta.-lactamase by the compound.