Clinical and Bacteriologic Studies of the Effect of Massive Doses of Penicillin G on Infections Caused by Gram-Negative Bacilli

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Abstract
INFECTIONS due to gram-negative bacilli are presently increasing in frequency and difficulty of management. One approach to the therapy of this type of disease has been a search for and development of more effective antimicrobial compounds. Another possibility that has received little attention is the use of some of the "old" antibiotics in doses higher than those conventionally employed. When penicillin G was first used clinically, the limited quantities available dictated its application in situations involving highly "sensitive" organisms (1 to 2 units per milliliter) such as pneumococci, Streptococcus pyogenes, penicillinase-negative staphylococci and some strains of neisseria. That other . . .