Metronidazole for vaginal trichomoniasis. Seven-day vs single-dose regimens

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Abstract
This randomized, double-blind evaluation of metronidazole therapy for trichomonal vaginitis compared the efficacy and side effects of a single 2-g dose and the standard 7-day regimen (250 mg 3 times daily). Eighty (86%) of the 93 women examined 7-21 days after therapy with the 2-g regimen and 76 (91.6%) of 83 examined after the 7-day regimen were cured. These cure rates were not significantly different. Symptom duration and the occurrence of side effects and yeast infection were not significantly different for the 2 treatment groups. Because the efficacy and side effects of the 2 regimens are comparable and the 2-g dose is easier to administer and less expensive, the 2-g dose as standard treatment for trichomoniasis is recommended.

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