Circulating immune complexes from HIV‐1+ patients induces apoptosis on‘qc normal lymphocytes
Open Access
- 1 November 1997
- journal article
- research article
- Published by Wiley in Immunology
- Vol. 92 (3) , 317-320
- https://doi.org/10.1046/j.1365-2567.1997.00361.x
Abstract
Isolated immune complexes from sera of 49 out of 67 human immunodeficiency virus-1-positive (HIV-1+) patients (CIC–HIV+), composed of anti-HIV–HIV-Ag, could induce apoptosis on normal phytohaemagglutinin (PHA)-activated lymphocytes. DNA degradation was detected by propidium iodide staining. This activity is directed against CD4+ lymphocytes as demonstrated by double binding of CIC–HIV+ and anti-CD4 on apoptotic cells. Expression of Fas antigen is prior to apoptotic phenomena. CIC–HIV+ apoptosis inducers belong mainly to asymptomatic HIV-infected patients, indicating that immune complexes from these patients can destroy CD4+ lymphocytes.Keywords
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